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Mini review

Herpes simplex virus type 1 persists in the aged brain through hypothetical expression of accessory genes

Pages 203-207 | Received 15 Jan 2010, Accepted 27 Feb 2010, Published online: 07 May 2010
 

Abstract

Herpes simplex virus type 1 persists in the brain of most aged individuals and may contribute to the pathogenesis of Alzheimer's disease. The virus likely utilizes accessory genes for neural spread within the nervous system and herpes simplex virus type 1 may regulate various host responses through an array of accessory genes. This mini-review focuses on these viral accessory genes that may shed light on the potential mechanisms of this enigmatic phenomenon in the elderly brain.

Declaration of interest: The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.

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