Changes in copper and zinc serum levels in women wearing a copper TCu-380A intrauterine device

Abstract

Objective To assess the effects of the copper intrauterine device (IUD) TCu-380A, on copper and zinc serum levels.

Material and methods This longitudinal study enrolled 121 women attending Health Centres in Tehran between November 2011 and August 2012. A blood sample was obtained before use and three months after insertion of a TCu-380A IUD. Serum levels of copper and zinc were measured for the 101 women who had completed three months with the device in situ. Analyses of change included paired t-tests, McNemar tests and linear regression.

Results Significant elevations in mean serum levels were found for both copper (170.22 μg/dl at three months vs.160.40 μg/dl at baseline, p = 0.034) and zinc (107.67 μg/dl at three months vs. 94.61 μg/dl at baseline, p < 0.001) three months after IUD insertion.

Conclusions A slight, but significant increase in copper serum levels, not reaching toxic levels, was observed three months after TCu-380A IUD insertion. Zinc levels too had risen significantly, which was quite unexpected, and warrants further investigation.

KEYWORDS:

• TCu-380A IUD
• Copper
• Zinc

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and the writing of the paper.