Fatal invasive trichosporonosis due to Trichosporon loubieri in a patient with T-lymphoblastic lymphoma

Abstract

This study describes the third known human case of an invasive infection caused by Trichosporon loubieri. The 21-year-old patient was suffering from a third relapse of T-lymphoblastic lymphoma and had been in pancytopenia for three months when she developed a blood trichosporonosis. The patient died 10 days later, despite intravenous voriconazole therapy. Final unequivocal identification of the strain was done using molecular biology tools.

Keywords:

• Trichosporon loubieri
• molecular diagnosis
• blood infection

Acknowledgements

The authors would like to acknowledge the Genotyping and Sequencing facility of Bordeaux for participating to the sequencing of ITS and 18S rDNA.

Declaration of interest: The authors report no conflicts of interest. The authors are responsible for the content and writing of the paper.

This paper was first published online on Early Online on 21 October 2010.