High fasting serum glucose in non-diabetic subjects ≥45 years is an indicator of future cardiovascular events as it is positively associated with atherogenic index of plasma

Abstract

Background: Atherogenic index of plasma, a newly emerging lipid parameter, has been employed only in a few studies in diabetics and not at all in non-diabetics.

Methods: Association between fasting serum glucose and lipid parameters in 321 non-diabetic males aged 30 to 60 years was studied retrospectively. Glucose and lipid parameters were measured on fully automated analyser using standard reagent kits. Body mass index was also ascertained.

Results: On comparing the various lipid parameters between normo-glycaemic and pre-diabetic men, a significant increase in TG (p = 0.0328), VLDL-C (p = 0.0328) and AIP (p = 0.0373) was observed only in pre-diabetic men ≥ 45 years. In non-diabetic men ≥ 45 years a slight but statistically positive correlation between glucose and AIP was also seen.

Conclusions: Increased blood glucose in men ≥ 45 years, even in the non-diabetic range is associated with increased risk of CVD, as indicated by an increased atherogenic index of plasma.

Keywords::

• Serum glucose
• AIP index
• serum TG
• total cholesterol
• non-diabetic

Acknowledgements

We are indebted to the staff of the Department of Biochemistry, SRMS. Medical College and Hospital, Bareilly, Uttar Pradesh, India, for their technical assistance. All authors contributed to the skilful editing of the manuscript and interpretation of results.

Declaration of interest

Please confirm that the authors report no conflicts of interest.