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Archives of Physiology and Biochemistry
The Journal of Metabolic Diseases
Volume 122, 2016 - Issue 2
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Original Article

Age, weight and decompression sickness in rats

Peter BuzzacottLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France, ;The School of Sports Science, Exercise and Health, The University of Western Australia, Crawley, WA, Australia, and Correspondence[email protected]
,
Michael TheronLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,
,
Aleksandra MazurLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,
,
Qiong WangLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,
,
Kate LambrechtsLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,
,
Ingrid EftedalDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
,
Simin Berenji ArdestaniDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
&
François GuerreroLaboratoire Optimisation des Régulations Physiologiques (ORPhy), UFR Sciences et Techniques, Université de Bretagne Occidentale, Brest Cedex, France,
show all
Pages 67-69 | Received 16 Oct 2015, Accepted 07 Jan 2016, Published online: 12 Mar 2016
 
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Abstract

Objective: The aim of this study was to determine if, after controlling for weight, age is associated with decompression sickness (DCS) in rats. Methods: Following compression-decompression, male rats aged 11 weeks were observed for DCS. After two weeks recovery, surviving rats were re-dived using the same compression-decompression profile. Results: In this experiment, there was a clear difference between DCS outcome at ages 11 or 13 weeks in matched rats (p = 0.002). Discussion: Even with weight included in the model, age was significantly associated with DCS (p = 0.01), yet after removal of weight the association was much stronger (p = 0.002). Conclusion: We believe that age is likely to be found associated with the probability of DCS in a larger dataset with a wider range of parameters, after accounting for the effect of weight.

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