Incorporation in vivo Des Acides Palmitique Et Oléilque Marqués Dans Les Lipides Du Muscle Squelettique Chez Le Rat Normal Et Thyréioprive Au Cours D'une Épreuve De Nage

Abstract

The purpose of this work was to study the incorporation of [1-¹⁴C] palmitic and [9,10-³H] oleic acids, after intravenous administration in the lipids of rat hind leg muscles. The animals were fasting or fed, at rest or swimming during 10 min before test, euthyroid or thyroidectomised. All these animals have been taking the same daily swimming training, during 15 days before the injection of labelled molecules. They were killed 10 min (±1) later.

The lipidic muscle composition, the incorporation rate of labelled fatty acids in these lipids and the radioactivity distribution among the different lipids in the various cases have been determined. Moreover the plasmatic non-esterified acid radioactivity has been measured.

These various values are affected by nutritional, hormonal state, and by physical activity of the animals. Particularly, it seems that supplementary energy spent during swimming test will be covered by the oxidation of different nutriments, according to the nutritional and hormonal state of animals.