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Abstract
The influence of temperature on the acid-base status of normal human deoxygenated whole blood was studied in open systems (variable total CO2 content).
(1) When the temperature was raised from 26 °C to 42 °C, the apparent buffering value of deoxygenated whole blood for CO2 increased by 7% of its value at 26 °C; this increase was not statistically significant.
(2) Comparing the present data with those obtained previously from oxygenated whole blood in the same temperature range (Castaing & Pocidalo, 1979) indicates that arterial and venous blood have slightly different buffering capacities for CO2 in the 26 to 42 °C temperature range. It also suggests that, at physiological SO2 levels (SO2 × 30%), the apparent buffering value of venous blood for CO2 would be increased by at least 10% of its value at 26 °C when the temperature is raised to 42 °C.
(3) It is concluded that pH stability would be reduced upon CO2 uptake within tissues with a high metabolism and therefore a high temperature.