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Ophthalmic Genetics Volume 37, 2016 - Issue 2
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Letters to the Journal

The TNF-α-308G/A Polymorphism is Not Associated with Ocular Chlamydia trachomatis Infection in Han Chinese Children

Wenwen XueDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center, Shanghai, China, ;Department of Ophthalmology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, China, and
,
Qingzhong WangBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
,
Zhiqiang LiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
,
Lina LuDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center, Shanghai, China,
,
Jianfeng ZhuDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center, Shanghai, China,
,
Xiangui HeDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center, Shanghai, China,
,
Rong ZhaoDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center, Shanghai, China,
,
Yongyong ShiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China
&
Haidong ZouDepartment of Preventative Ophthalmology, Shanghai Eye Diseases Prevention & Treatment Center, Shanghai, China, ;Department of Ophthalmology, Shanghai First People’s Hospital, Shanghai Jiao Tong University, Shanghai, China, and Correspondence[email protected]
 show all
Pages 245-247 | Received 24 Nov 2014, Accepted 07 Mar 2015, Published online: 15 Jan 2016
 
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Abstract

Objective: To investigate the association between the TNF-α-308G/A polymorphism and ocular chlamydia trachomatis (C. Trachomatis) infection among Han Chinese children.

Methods: 248 patients and 162 matched healthy controls were recruited. The diagnosis of ocular C. Trachomatis infection was given after clinical observation and latex immunochromatography tests. The TNF-α-308G/A polymorphism was genotyped by sequencing.

Results: No association was found between the TNF-α-308G/A polymorphism and ocular C. Trachomatis infection.

Conclusions: The TNF-α-308A polymorphism is unlikely to play a major role in the risk for ocular C. Trachomatis in the Chinese population.

Acknowledgements

We thank all the eye diseases prevention workers who participated in this study.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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