Experimental models of anterior segment dysgenesis

Abstract

Normal anterior segment embryogenesis is summarized followed by a review of syndromes of spontaneous and inherited conditions of abnormal development in humans and animals. The study of teratogen-induced malformations in animal models has provided valuable information about critical periods during gestation for the initiation of anterior segment dysgenesis. Although the major developmental events leading to iridocorneal angle formation occur during the third trimester, it appears that embryonic insult much earlier in human gestation (during the first three to five weeks post fertilization) can induce an abnormal sequence of events leading to anterior segment dysgenesis.

Key Words:

• animal model
• Axenfeld's anomaly
• congenital cataract
• congenital glaucoma
• goniodysgenesis
• keratolenticular dysgenesis
• Peters' anomaly
• persistent pupillary membranes
• posterior embryotoxon
• Rieger's anomaly
• teratogen