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Human Fertility
an international, multidisciplinary journal dedicated to furthering research and promoting good practice
Volume 18, 2015 - Issue 2
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ORIGINAL ARTICLE

Glutathione S-transferase M1 and T1 gene polymorphisms and risk of endometriosis in Tunisian population

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Pages 128-133 | Received 26 Apr 2014, Accepted 09 Jul 2014, Published online: 30 Dec 2014
 

Abstract

Objective: An association between endometriosis and the glutathione S-transferase M1 (GSTM1)- and GSTT1-related genes has been proposed on account of the detoxification properties of the GST enzymes. The aim of the present study was to investigate whether the polymorphisms and null mutations are associated with the susceptibility to endometriosis. Methods: The study included 105 women with endometriosis and 150 healthy women with no laparoscopic evidence of disease. Genotyping of the GSTM1 and GSTT1 gene polymorphisms was performed by Multiplex-PCR. Results: There was a significant association of GSTM1 null and GSTT1 null genotypes with endometriosis both when studied alone (P = 0.001 and P = 0.03, respectively) and in combination (P = 0.00002). Conclusion: The findings suggest that the GSTM1 and GSTT1 gene deficiency predisposes to endometriosis in a Tunisian population and can confer a significant increased risk when the GST null genotypes are combined.

Acknowledgments

Many thanks to Professor A. Hamzaoui, head of the unit research UR12SP15.

Funding

This study was supported by a grant from the Ministry of Science and Technology and the Ministry of Health of Tunisia.

Declaration of interest: The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.

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