Abstract
We report a case of trisomy 21 in a fetus presenting with normal nuchal translucency and acute changes in the ductus venosus within the same ultrasound examination at 15 weeks of gestation. Ultrasound scan revealed an echogenic foci in the left ventricle, bilateral mild pyelectasis and bilateral clubfoot. Karyotyping by amniocentesis led to the diagnosis of trisomy 21. We believe this to be the first case report of ductus venosus dramatical changes detected in a very short time in a fetus affected by trisomy 21.