Reaction of Dipeptidylpeptidase IV with Substrate-Analogous Azapeptides

U. Neumann Institute of Pharmacology and Toxicology, Medical Academy Erfurt, 5010-Erfurt, Nordhäuserstr. 74GDR

T. Steinmetzer Dept. of Biotechnology, Martin Luther University Halle, Domplutz 1, 4020, Halle, GDR

A. Barth Dept. of Biotechnology, Martin Luther University Halle, Domplutz 1, 4020, Halle, GDR

H.-U. Demuth Dept. of Biotechnology, Martin Luther University Halle, Domplutz 1, 4020, Halle, GDR

Abstract

The reaction of dipeptidyl peptidase IV (EC 3.4.14.5.) with azapeptide substrates containing azaalanine or azaproline in the P₁-position was investigaled. Accumulation of a fairly stable acyl-enzyme could be shown for ester substrates. Ala-AzaPro-pNA is a very poor substrate of DP IV and does not accumulate an acyl-enzyme. DP IV does not react with active-site titrants for trypsin-like serine proteases.

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Reaction of Dipeptidylpeptidase IV with Substrate-Analogous Azapeptides

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Reaction of Dipeptidylpeptidase IV with Substrate-Analogous Azapeptides

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