Wound healing after laser skin resurfacing: The effect of a silver sulfadiazine-hyaluronic acid-containing cream under an occlusive dressing

Abstract

Introduction: Occlusive dressings promote wound healing after laser skin resurfacing. Our goal was to evaluate whether a cream containing hyaluronic acid–silver sulfadiazine could improve this process. Methods: Ten guinea pigs received laser resurfacing on the skin of their backs. Polyurethane foam film adhesive dressing was applied. A cream containing hyaluronic acid–silver sulfadiazine was applied under the dressing over half of the wound. Skin biopsies were taken at days 2, 4, 7 and 9 and examined by a pathologist blinded to the study. Results: Re-epithelialization appeared to occur faster in the cream-treated areas, together with a lower level of acute inflammation in the early phase of the healing process. Conclusions: The cream containing silver sulfadiazine/hyaluronic acid seems to improve wound healing after laser skin resurfacing in guinea pigs. The clinical application of this finding on humans should be assessed.

Key Words::

• Hyaluronic acid
• laser skin resurfacing
• silver sulfadiazine
• wound healing

Acknowledgements

We thank Mr Konstantinos Marayiannis and Mrs Maria Hountasi for their excellent technical support.

The expenses for the completion of the experimental phase of the present work were covered by the company importing and distributing the silver sulfadiazine–hyaluronic acid cream (Ialuset) in Greece.

No other financial associations exist between anyone or any company and any of the authors that could create a conflict of interest with this work.

The paper has not been presented at any meeting

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.