Minocycline for the treatment of cutaneous silicone granulomas: A case report

Abstract

Silicone oil injections are often used for soft tissue augmentation and local and general adverse effects occurring from a few months to 15 years after injection have been reported. Here, we present a case of delayed granuloma formation due to liquid injectable silicone with large extent of involvement, which precluded surgical removal. Our patient was successfully treated with minocycline, considering its anti-inflammatory, immunomodulating and antigranulomatous properties. This case presents minocycline monotherapy as a useful treatment option for the management of severe granuloma induced by silicone use when surgical excision is not possible.

Key Words::

• foreign-body granuloma
• minocycline
• silicone oils

Declaration of interest: The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.

ORCID

Elisete Crocco http://orcid.org/0000-0002-8844-2887

Renata Alves http://orcid.org/0000-0001-6441-4091