223
Views
26
CrossRef citations to date
0
Altmetric
Original Article

Family history of diabetes mellitus as an independent risk factor for macrosomia and cesarean delivery

, , , &
Pages 148-152 | Received 09 Feb 2009, Accepted 25 Jun 2009, Published online: 15 Jan 2010
 

Abstract

Objective. To test the association between familial history of diabetes mellitus and birth-weight as well as mode of delivery stratified for the presence of the disease.

Methods. A population-based study, comparing birth outcome of patients with and without familial history of diabetes mellitus was conducted. Patients lacking prenatal care were excluded from the analysis. Multiple logistic regression models were used to control for confounders. The Mantel–Haenszel procedure was used to obtain the weighted odds ratios while controlling for the presence of diabetes mellitus (either gestational or pre-gestational).

Results. Out of 181,479 deliveries, 7.6% (n = 13,813) were in patients with familial history of diabetes mellitus. These patients had higher rates of diabetes mellitus (either gestational or pre-gestational) as compared with patients without familial history of diabetes mellitus (13.7% vs. 6.3%, OR = 2.3; 95% CI 2.2–2.5, p < 0.001). Patients with familial history of diabetes mellitus had higher rates of macrosomia (birth-weight >4 kg; 5.7% vs. 4.6%, p < 0.001). Also, a 1.3-fold increase in the risk for cesarean delivery (CD) was found in patients with familial history of diabetes mellitus as compared with the comparison group (17.1% vs. 13.8%, p < 0.001). Using two different multiple logistic regression models, one with CD and the second with macrosomia as the outcome variable, the association between familial history of diabetes mellitus and these complications remained significant (OR = 1.2; 95% CI 1.1–1.2; p < 0.001 and OR = 1.2; 95% CI 1.03–1.2; p = 0.005, respectively). The two models controlled for important confounders such as diabetes mellitus and the year of delivery, in order to control for ascertainment bias.

Conclusion. Family history of diabetes mellitus has a significant, independent association with the risk for macrosomia and CD during pregnancy, regardless the presence of the disease.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Log in via your institution

Log in to Taylor & Francis Online

PDF download + Online access
  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart
* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.