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Case Reports

Transient ventricular hypocinesia after in utero anthracyclines exposure: a case-report and review of the literature

, , , , &
Pages 189-192 | Received 29 Nov 2010, Accepted 17 Jan 2011, Published online: 02 Mar 2011
 

Abstract

Due to the low occurrence of cancer during pregnancy, limited data are available about outcome of infants exposed to chemotherapy in utero. We report the case of a newborn who developed transient ventricular hypocinesia and late-onset infection after in utero exposure to four epirubicin cycles for pregnancy-associated breast cancer. Moreover, we provide an overview of literature on neonatal outcome after anthracyclines-based chemotherapy regimen during pregnancy. Existing data support use of anthracyclines, as few cases of fetal cardiac toxicity were reported and most of short-term complications were transient. Need for prospective collection of data and longer follow-up is highly recognized.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article.

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