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The Journal of Maternal-Fetal & Neonatal Medicine Volume 25, 2012 - Issue 5
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Original Article

Lutein and zeaxanthin supplementation in preterm infants to prevent retinopathy of prematurity: a randomized controlled study

Carlo DaniDepartment of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, ItalyCorrespondence[email protected]
,
Ilaria LoriDepartment of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy
,
Federica FavelliDepartment of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy
,
Saverio FrosiniDepartment of Oto-Neuro-Ophthalmological Surgical Sciences, University of Florence, Firenze, Italy
,
Hubert MessnerNeonatal Intensive Care Unit of Ospedale Regionale, Bolzano, Italy
,
Petra WankerNeonatal Intensive Care Unit of Ospedale Regionale, Bolzano, Italy
,
Sergio De MariniDivision of Neonatology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
,
Chiara OrettiDivision of Neonatology, Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy
,
Antonio BoldriniDivision of Neonatology and Neonatal Intensive Care Unit, S. Chiara Hospital, University of Pisa, Pisa, Italy
,
Ciantelli MassimilianoDivision of Neonatology and Neonatal Intensive Care Unit, S. Chiara Hospital, University of Pisa, Pisa, Italy
,
Patrizia BragettiDivision of Neonatology and Neonatal Intensive Care Unit, University of Perugia, Perugia, Italy
&
Cristiana GerminiDivision of Neonatology and Neonatal Intensive Care Unit, University of Perugia, Perugia, Italy
 show all
Pages 523-527 | Received 18 Jul 2011, Accepted 28 Sep 2011, Published online: 18 Nov 2011
 
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Abstract

Objectives: Lutein and its isomer zeaxanthin (L/Z) function in the eye as antioxidant agents and blue-light filters. Our aim was to evaluate whether their administration could help decrease the occurrence of retinopathy of prematurity (ROP) in preterm infants. Methods: Infants with gestational age ≤32 weeks were randomly assigned to receive a daily dose of L/Z (0.14 + 0.006 mg) or placebo until discharge. Results: ROP occurrence was similar in the L/Z (11/58; 19%) and placebo (15/56; 27%) groups, as the occurrence of ROP at each stage and the need of eye surgery. Conclusion: L/Z supplementation was ineffective in preventing ROP in preterm infants and did not affect the outcome at discharge of our patients.

Acknowledgment

We want to thank Sooft Italia Spa for its generosity in providing lutein/zeaxanthin and placebo. Trial registration: ISRCTN10624844.

Declaration of interest: The authors declared no conflict of interest.

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