Abstract
Objectives: To investigate the association of 1082G > A(RsaI) (rs1256049) and 1730A > G(AluI) (rs4986938) single nucleotide polymorphisms(SNPs), respectively – located on estrogen receptor β (ESR2) gene with recurrent spontaneous abortion (RSA) in Chinese population. Methods: The study group consisted of 196 patients with RSA and 182 fertile women as control. Two functional polymorphisms 1082G > A (a silent mutation in exon 5) and 1730A > G (3′ nontranslated region of the exon 8) of ESR2 were studied by association analysis. Results: There were no significant differences between ESR2 gene polymorphisms and RSA (χ2 = 1.793, P = 0.408; χ2 = 1.432, P = 0.489, respectively). Conclusion: The present data indicate that the studied SNPs on ESR2 gene may not be associated with RSA in Chinese population.
Acknowledgements
We thank the patients and controls for their voluntary Participation in this study.
Declaration of Interest: This work was supported by the University Natural Science Foundation of Anhui in China (KJ2009A77).