IGF2/ApaI polymorphism associated with birth weight in children of the region of Petrolina–PE, Brazil

Abstract

Insulin-like growth factor 2 (IGF2) gene has an important role in fetal growth. It was investigated association of the IGF2/ApaI polymorphism with low birth weight and normal birth weight (as control) in children attended in Hospital Dom Malan Petrolina, PE-Brazil. The genotype frequencies did not differ statistically between low birth weight (AA = 16.22%, AG = 43.24%, GG = 40.54%) and control (AA = 20% AG = 35%, GG= 45% groups) and the allele frequencies were not significantly different (p > 0.05).The observed genotype frequencies in both groups did not deviate significantly from Hardy–Weinberg equilibrium. Then, no significant correlation was found for this polymorphism in the population studied.

Keywords::

• IGF2
• low birth weight
• genotype
• alleles

Acknowledgments

We thank to Prof. Paulo Roberto Eleutério de Souza for assistance with statistical analysis. We also thank the staff of the Dom Malan Hospital-IMIP, Petrolina-PE; mothers of children and students of Medicine–UNIVASF for help in collection blood.

Declaration of Interest: Financial support was received from CNPq. The authors report no declaration of interest.