Does transient hypothyroxinemia influence metabolic bone disease of prematurity?

Abstract

Objective: To investigate the relationship between Metabolic Bone Disease (MBD) and Transient Hypothyroxinemia of Prematurity (THOP).

Method: One hundred twenty-four infants, born in Marmara University Hospital with a gestational age ≤34 weeks, were enrolled. Clinical features were recorded. Serum TSH, free T₄, total T₄, calcium, phosphorus and total Alkaline Phosphatase (ALP) levels were determined in the first and third postnatal weeks. MBD was defined as a phosphorus level <4.5 mg/dl and/or ALP >900 IU/l. THOP was defined as a serum free and/or total thyroxine level lower than −1 SD for gestational age at the 7th postnatal day.

Result: THOP was diagnosed in nineteen (15.3%) patients. MBD was diagnosed in 52 (41.9%) at the 3rd month. Low birth weight, low gestational age and prolonged parenteral nutrition were associated with MBD. Multivariate analysis documented a significant relationship solely between MBD and gestational age.

Conclusion: The risk of MBD does not increase significantly in babies with THOP.

• Alkaline phosphatase
• metabolic bone disease
• prematurity
• thyroid hormones
• transient hypothyroxinemia