Abstract
Background: The main hydrosoluble metabolites in three different human congenital pulmonary malformations are described by nuclear magnetic resonance (NMR) spectroscopy.
Methods: Bronchogenic cyst (BC), congenital lobar emphysema (CLE) and intrapulmonary sequestration (IPS), were analyzed with respect to a control sample. The extracted metabolites were submitted to high-resolution 1H NMR-spectroscopy.
Results: Congenital lung malformations showed free choline, phosphocoline and myoinositol high levels. IPS and CLE were found increased in lactic acid/glucose ratio. Lactic acid and glucose values resulted to be more elevated in control sample.
Conclusions: Congenital lung lesions showed different metabolomic profiles useful for early diagnosis.
Acknowledgements
We wish to acknowledge the “Associazione Bambini con la CCAM” for supporting research in our Pediatric Surgery Unit.
Declaration of interest
There are no conflicts of interest regarding the publication of this article.