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The Journal of Maternal-Fetal & Neonatal Medicine Volume 29, 2016 - Issue 9
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Original Article

The impact of assisted reproductive technology and chorionicity in twin pregnancies complicated by obstetric cholestasis

Giuseppina Pacella1 Department of Obstetrics and Gynecology, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
,
Ginevra Salsi1 Department of Obstetrics and Gynecology, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
,
Tiziana Arcangeli1 Department of Obstetrics and Gynecology, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
,
Aly Youssef1 Department of Obstetrics and Gynecology, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
,
Antonio Farina1 Department of Obstetrics and Gynecology, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
,
Maria Letizia Bacchi-Reggiani2 Cardiology Unit-Department of Experimental, Diagnostic and Specialty Medicine, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
,
Federica Bellussi1 Department of Obstetrics and Gynecology, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
,
Giuseppe Mazzella3 Department of Digestive Diseases and Internal Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy, and
,
Francesco Azzaroli3 Department of Digestive Diseases and Internal Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy, and
,
Eleonora Porcu1 Department of Obstetrics and Gynecology, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
,
Nicola Rizzo1 Department of Obstetrics and Gynecology, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy,
&
Tullio Ghi4 Department of Obstetrics and Gynecology, Maggiore Hospital, University of Parma, Parma, ItalyCorrespondence[email protected]
 show all
Pages 1481-1484 | Received 11 Dec 2014, Accepted 13 May 2015, Published online: 05 Jun 2015
 
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Abstract

Objective: To assess in a cohort of twin pregnancies the prevalence of obstetric cholestasis (OC) and its correlation with the type of conception and chorionicity.

Methods: A retrospective cohort study including all the twin pregnancies delivered between 2005 and 2013 at our University Hospital was carried out. In the study population, the prevalence of OC was investigated in relationship to the impact of assisted reproductive technology (ART) and of chorionicity.

Results: Overall, 569 twin pregnancies were included in the study population. Among those complicated by OC, the rate of ART was 3-fold higher (OR 3.4, 95% CI 1.2–9.5, p = 0.02), whereas the rate of dichorionicity did not differ significantly (OR 1.6, 95% CI 0.3–7.9, p = 0.53).

Conclusion: The risk of developing OC seems to be significantly higher among twin pregnancies obtained after ART in comparison with those conceived spontaneously.

Declaration of interest

The authors report no declarations of interest.

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