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The Journal of Maternal-Fetal & Neonatal Medicine Volume 30, 2017 - Issue 2
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Short Report

Cytomegalovirus non-primary infection during pregnancy. Can serology help with diagnosis?

O. PiconeService de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Foch, Suresnes, France, ;Collège Français d’échographie Foetale (CFEF), Chateaubriant, France, ;EA2493, UFR des Sciences de la Santé Simone Veil, UVSQ, Montigny le Bretonneux, France,
,
L. Grangeot-KerosAP-HP, Hôpital Paul Brousse, Groupe Hospitalier Universitaire Paris-Sud, Virologie, WHO Rubella NRL, National Reference Laboratory for Maternofetal Rubella Infections, Univ Paris-Sud, INSERM U1193, Villejuif, France,
,
Mv SenatService de Gynécologie-Obstétrique, Hôpital Kremlin Bicêtre (AP-HP), Université Paris Sud, Bicetre, France, and
,
F. FuchsService de Gynécologie-Obstétrique, Hôpital Kremlin Bicêtre (AP-HP), Université Paris Sud, Bicetre, France, and
,
E. BouthryAP-HP, Hôpital Paul Brousse, Groupe Hospitalier Universitaire Paris-Sud, Virologie, WHO Rubella NRL, National Reference Laboratory for Maternofetal Rubella Infections, Univ Paris-Sud, INSERM U1193, Villejuif, France,
,
Jm AyoubiService de Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Foch, Suresnes, France, ;EA2493, UFR des Sciences de la Santé Simone Veil, UVSQ, Montigny le Bretonneux, France,
,
A. BenachiService de Gynécologie-Obstétrique, Hôpital Antoine Béclère (AP-HP), Université Paris Sud, Clamart, France
&
C. Vauloup-FellousAP-HP, Hôpital Paul Brousse, Groupe Hospitalier Universitaire Paris-Sud, Virologie, WHO Rubella NRL, National Reference Laboratory for Maternofetal Rubella Infections, Univ Paris-Sud, INSERM U1193, Villejuif, France, Correspondence[email protected]
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Pages 224-227 | Received 31 Jan 2016, Accepted 20 Mar 2016, Published online: 05 May 2016
 
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Abstract

Diagnosis of cytomegalovirus (CMV) primary infection is reliable, but diagnosis of CMV non-primary infection (NPI) is questionable. Our aim is to highlight the difficulties met in diagnosis of CMV NPI. We illustrate that in proven cases of CMV NPI, very different serologic and molecular patterns may be observed and that routine serologic testing may fail to help with diagnosis. These results point out that many data available in literature concerning the prevalence of NPI, materno-fetal transmission rates and consequences of NPI may be wrong. We need to know how frequently they occur, are transmitted and cause fetal damages. Diagnosis of NPI must be improved, along with our understanding of the mechanisms leading to intrauterine CMV transmission and congenital infection in babies born to women with preexisting immunity.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.

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