Alteration of functional connectivity in tinnitus brain revealed by resting-state fMRI?: A pilot study

Abstract

Objective: We report a case study on possible alterations in resting-state functional connectivity between the auditory network and non-auditory brain regions in tinnitus patients. Design: Independent component analyses were performed to evaluate coherent spontaneous activity in distributed brain networks. The resting-state functional connectivity scores between the right and left auditory networks were measured. Direct comparison of resting-state connectivity between tinnitus patients and controls was made using a two-sample t-test. Study sample: Four patients (three male, one female; mean age 45 ± 3.92 years) with chronic tinnitus lateralized to the left ear, and six age-matched controls (four male, two female; mean age 45 ± 2.76 years) participated in this case study. Results: The average resting-state functional connectivity (FC) score between the left and right auditory cortical regions was significantly lower in tinnitus patients than in controls (P < 0.05). Direct comparison between patients and controls showed that increased functional connectivity caused by tinnitus occurred predominantly in the left amygdala and in the dorsomedial prefrontal cortex. Conclusions: Our pilot study suggested that resting state functional magnetic resonance imaging (fMRI) could be useful to investigate possible alterations in resting-state neuronal activity between the auditory and non-auditory networks in tinnitus patients.

Key Words::

• Tinnitus
• auditory cortex
• emotion
• hearing
• functional connectivity
• resting-state fMRI

Acknowledgements

This work was supported by the Ministry of Health & Welfare, Korea (A092106). Ji-young Kim and Yee-hyuk Kim contributed equally to this work.

Declaration of interest: The authors report no conflict of interest.