Pain Management Discussion Forum: Serious Interaction Among Frequently Used Drugs for Chronic Pain

ABSTRACT

A query and response regarding a patient who was taking high-dose tramadol and duloxetine is presented. The patient developed serotonin syndrome. Risks for this clinically important drug interaction and management of the syndrome are discussed.

This report is adapted from paineurope 2013; Issue 4, ©Haymarket Medical Publications Ltd., and is presented with permission. paineurope is provided as a service to pain management by Mundipharma International, Ltd., and is distributed free of charge to health care professionals in Europe. Archival issues can be accessed via the Web site: http://www.paineurope.com, at which European health professionals can register online to receive copies of the quarterly publication.

KEYWORDS :

• cyproheptadine
• drug
• interaction
• duloxetine
• pain
• serotonin syndrome
• tramadol