A new method for the determination of 2,2′-dichloro-4,4′-methylenedianiline in workplace air samples by HPLC-DAD

Abstract

A new procedure has been developed for the assay of 2,2′-dichloro-4,4′-methylenedianiline (MOCA) using high-performance liquid chromatography with diode array detector. MOCA was sampled from workplace air and derivative before determination using 3,5-dinitrobenzoyl chloride. The determination was carried out in the reverse-phase system (mobile phase: acetonitrile: water) using an Ultra C₁₈ column. The measurement range was 2–40 µg/m³ for a 100 dm³ air sample. Limit of detection: 7.9 ng/m³ and limit of quantification: 23.8 ng/m³.

Keywords::

• 4,4′-Methylenebis(2-chloroaniline)
• MOCA
• MBOCA
• analytical method
• workplace air