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Clinical Toxicology Volume 48, 2010 - Issue 4
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Short Reports

Bupropion toxicokinetic: A case report

Kieran Donnelly Department of Anaesthetics, UHB NHS Trust, Sellyoak, Birmingham, UKCorrespondence[email protected]
,
Hannah Beth Walkowiak City Hospital, Birmingham, West Midlands, UK
,
Christopher Donnelly Mathematics Department, Trinity College, Cambridge University, Cambridge, UK
,
Emma Jenkinson Heartlands NHS Trust, Birmingham, West Midlands, UK
,
Jonha Rizkalla Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, West Midlands, UK
&
Nigel Langford Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, West Midlands, UK; West Midlands Centre for Adverse Drug Reaction Reporting, City Hospital, Birmingham, West Midlands, UK
Pages 385-387 | Received 08 Nov 2009, Accepted 14 Jan 2010, Published online: 16 Mar 2010
 
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Abstract

Context. The toxicokinetics of sustained-release bupropion are not well described. Case. A 23-year-old Caucasian male took an overdose of 5,700 mg of sustained release bupropion with no co-ingestant. Venous serum samples were assayed for bupropion concentrations over the next 5 days. The peak concentration was 1.114 mg/L. The observed Tmax was found to be 8.25 h, the calculated alpha half-life 10.9 h (±SE of 4.47%), and the calculated beta half-life 19.8 h (±SE 12.62%). The alpha half-life and Tmax differ significantly from those seen in therapeutic doses. Discussion. Bezoar formation may underlie these differences. Interventions which reduce the absorption of sustained release bupropion may be effective in overdose.

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