Influence of Preservatives on Conjunctival Cells in Vitro

CAROLINE DEBBASCH Unité de Pharmacotoxicologie Cellulaire C.H.N.O. des XV-XX Paris, France

MAGDA DE SAINT JEAN Service d'Ophtalmologie Hôpital Ambroise Paré Boulogne, France

PIERRE-JEAN PISELLA Service d'Ophtalmologie Hôpital Ambroise Paré Boulogne, France

PATRICE RAT Unité de Pharmacotoxicologie Cellulaire C.H.N.O. des XV-XX Paris, France

JEAN-MICHEL WARNET Unité de Pharmacotoxicologie Cellulaire C.H.N.O. des XV-XX Paris, France

CHRISTOPHE BAUDOUIN Unité de Pharmacotoxicologie Cellulaire C.H.N.O. des XV-XX Paris, France

Abstract

Benzalkonium chloride (BAC), which is widely used in ophthalmic preparations for its preservative properties, has been shown to cause conjunctival toxicity. The purpose of this study was to examine the effects of BAC on a continuous human conjunctival cell line (Wong Kilbourne-derived human conjunctiva). Cytotoxicity tests were assessed according to ECVAM recommendations using microplate cold light

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Influence of Preservatives on Conjunctival Cells in Vitro

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Influence of Preservatives on Conjunctival Cells in Vitro

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