Relationships between cellular events and signaling pathways in various pesticide-affected neural cells

Abstract

Various pesticides are considered hazardous to human health. Of particular concern are potential problems of neurotoxicity associated with their use. Cellular toxicity may manifest as a variety of biological events, such as carcinogenesis (mutagenesis) and/or cell death. Recent reports indicate that signaling pathways regulate these cellular events. Thus, the toxicity of pesticides in cells may involve modulation of signaling pathways. In this review, we mainly focus on relationships between cellular events and signaling pathways in various pesticide-affected neural cells. Our data and those of related studies suggest that these pesticides affect both the viability and various signaling pathways of neural cells.

Keywords::

• PC12 cells
• neuronal differentiation
• organophosphate
• pyrethroid
• neonicotinoid

Acknowledgments

We thank Prof. Shoei Furukawa (Gifu Pharmaceutical University, Japan) for the kind donation of PC12 cells. We also thank Dr. Taisei Ishioka and Mr. Masakazu Yoshizumi (Gunma Prefectural Institute of Public Health and Environmental Sciences) for their technical help. This work was supported by Gunma prefecture.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.