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Toxin Reviews Volume 32, 2013 - Issue 4
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Review Article

Methods for chemical preparation of aflatoxin B1 adducts, AFB1-N7-guanine and AFB1-lysine

Daiane Cristina SassDepartment of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo Pirassununga, SPBrazil
,
Alessandra Vincenzi JagerDepartment of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo Pirassununga, SPBrazil
,
Fernando Gustavo ToninDepartment of Biossystem Engineering, School of Animal Science and Food Engineering, University of São Paulo Pirassununga, SPBrazil
,
Leandra Naira Zambelli RamalhoDepartment of Pathology, Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, SPBrazil
,
Fernando Silva RamalhoDepartment of Pathology, Medical School of Ribeirão Preto, University of São Paulo Ribeirão Preto, SPBrazil
,
Mauricio Gomes ConstantinoDepartment of Chemistry, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto, University of São Paulo Ribeirão Preto, SPBrazil
&
Carlos Augusto Fernandes OliveiraDepartment of Food Engineering, School of Animal Science and Food Engineering, University of São Paulo Pirassununga, SPBrazilCorrespondence[email protected]
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Pages 68-74 | Received 21 Aug 2013, Accepted 02 Oct 2013, Published online: 24 Oct 2013
 
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Abstract

Aflatoxin B1 (AFB1) is a hepatocarcinogen produced by fungi species of the genus Aspergillus. Dietary exposure to AFB1 is associated with increasing incidence of hepatocellular carcinoma. The biotransformation of AFB1 generates the adducts AFB1-N7-guanine and AFB1-lysine, which are used as biomarkers of human exposure to dietary AFB1 in epidemiological studies. This article presents a review of main studies on the use of AFB1 adducts as biomarkers of human exposure to AFB1, and the current status of chemical procedures for the preparation of AFB1-N7-guanine and AFB1-lysine as analytical standards.

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