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Abstract
Objective: This study manipulates the possible protective rule of Cerastes cerastes crude venom (CCV) in irradiated mice with γ-rays that induced cytogenetic and physiological injures. Methods: Male mice were grouped into (1) control, (2) diluted CCV: mice received via i.p. ⅓LD50 CCV in diluted dose over a period of 2 weeks. (3) Irradiated: mice whole body exposed to 5.5 Gy γ-rays. (4) Irradiated + diluted: mice received via i.p. ⅓LD50 CCV in diluted dose over a period of 2 weeks starting 1 h post-irradiation. Hematological measurements, levels of antioxidant enzymes in spleen and blood and sperms and cytogenetic analysis were determined for each group. Results: The results showed that the levels of (advanced oxidation protein products) AOPP, malondialdehyde (MDA), chromosome aberrations and hematological disorders significantly decrease whereas, the blood and spleen levels of glutathione (GSH) and normal sperm count were significantly increased. It could be concluded that the diluted doses of CCV (⅓LD50) are alleviated irradiation-induced biological injuries.