Effect of metal exposure in rats: amelioration by diallylsulphide

Abstract

The effect of diallylsuphide (DAS) was investigated on mercuric chloride (HgCl₂)-induced renal damage in rats. Oral administration of DAS (200 mg/kg) effectively inhibited the levels of antioxidant enzymes as compared to HgCl₂-treated group. Exposure to HgCl₂ also resulted in an increase in the uric acid, creatinine and blood urea nitrogen levels. A significant decrease in the uric acid, creatinine and blood urea nitrogen was also observed in DAS-pre-treated HgCl₂ group. The results suggest that DAS possesses significant potential as nephroprotective agent.

• Antioxidants
• diallylsulphide
• metal toxicity
• nephrotoxicity

Acknowledgement

This research project was supported by “Research Center of the Center for Female Scientific and Medical Colleges’’, Deanship of Scientific Research, King Saud University, Riyadh, Saudi Arabia.