Chelation of manganese by combining deferasirox, deferiprone and desferrioxamine in male rats as biological model

Abstract

Manganese (Mn) is an essential trace element for human nutrition but also a toxicant when humans are exposed to high concentration. The present study was undertaken to test the hypothesis that three known chelators deferasirox (DFX), deferiprone (L1) and desferrioxamine (DFO) might be more efficient as combined treatment than as single therapies in removing Mn(II) from the body. Animals were randomly divided into a control and toxic groups. Manganese chloride was administrated orally as low and high doses. Chelators were given orally (DFX and L1) or intraperitoneally (DFO) for 2 weeks. Mn concentration was determined by flame atomic absorption spectrometer (FAAS). The results showed that elimination of Mn from liver, kidney and lung tissues in the vehicle groups was noticeable. The chelation therapy results showed that all three chelators were able to remove Mn from body, although DFX was more effective than DFO and L1; furthermore the combined therapies were more efficient compared to the single therapies.

• Chelation therapy
• deferasirox
• deferiprone
• desferrioxamine
• manganese

Acknowledgements

The authors wish to acknowledge the head and director of Kerman Neuroscience Research Center and Shahid Bahonar University of Kerman Faculty Research Funds for their support of these investigations.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.