Effects of whole-body cryotherapy on a total antioxidative status and activities of antioxidative enzymes in blood of depressive multiple sclerosis patients

Abstract

Objectives. Oxidative stress (OS) plays an important role in the pathogenesis of multiple sclerosis (MS). In MS patients depression is often observed. Cryotherapy might have an effect on OS. The aim of this study was to compare the effects of whole body cryotherapy (WBCT) on changes in total antioxidative status (TAS) of plasma and activities of antioxidative enzymes in erythrocytes from depressive and non depressive MS patients. Methods. Twenty-two MS patients with secondary progressive disease course (12 depressive and 10 non depressive) were treated with 10 exposures in a cryochamber. Before and after WBCT the plasma TAS and the activities of superoxide dismutase (SOD) and catalase (CAT) in the erythrocytes were measured. Results. The level of TAS in depressive MS group was significantly lower than in non depressive MS (P < 0.0003). WBCT increased the level of TAS in depressive (P < 0.002) more than in non depressive MS patients (P < 0.01). WBCT treatment of MS patients resulted in the significant increase of TAS level in plasma but had no effects on activities of SOD and CAT. Conclusions. Our results indicate that WBCT suppresses OS in MS patients, especially in depressive patients.

Key words::

• Depression
• multiple sclerosis
• antioxidative systems
• cryotherapy
• oxidative stress

Acknowledgements

We thank Juha Oksa, PhD, Adjunct Professor, Finnish Institute of Occupational Health, Oulu Centre of Expertise for Health and the Work Ability/Physical Work Capacity team for supplying his data.

Statement of interest

None to declare.