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Abstract
With the aid of microangiography the vascularization in the amputation stumps of 108 rabbits was studied, both in extremities with normal circulation and in those supplied with collaterals. It was found that the vascularization of the normal leg was altered by amputation, with the development of newly-formed, pathological, spirally-twisted vessels. Closure of the stump with myoplasty, however, counteracted this vessel formation, and hypervascularization took place through normal arteries. After amputation of extremities supplied with collaterals, the influence of amputation on collateral function and vascularization in the amputation stump was dependent on the time interval between arterial occlusion and amputation.