Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats

Else Marie Pinholt Institute for Surgical Research, Rikshospitalet, University of Oslo, Norway, Tel +47-5-30 80 10, Fax +47-5-30 82 04

Eirik Solheim Institute for Surgical Research, Rikshospitalet, University of Oslo, Norway, Tel +47-5-30 80 10, Fax +47-5-30 82 04

Gisle Bang Department of Oral Pathology, Forensic Odontology, Norway, Tel +47-5-30 80 10, Fax +47-5-30 82 04

Einar Sudmann Hagavik Orthopedic Hospital, University of Bergen, Norway, Tel +47-5-30 80 10, Fax +47-5-30 82 04

Abstract

A composite of a local, sustained, drug-release system, Alzamer® bioerodible polyorthoester, and demineralized bone-matrix (DBM) particles implanted in the abdominal muscle of 89 Wistar rats induced cartilage and bone formation at the same rate as DBM when evaluated histologically and by ⁸⁵Sr uptake. the composite implant was technically easier to use than DBM alone.

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Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats

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Bone induction by composite of bioerodible polyorthoester and demineralized bone matrix in rats

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