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Acta Orthopaedica Scandinavica Volume 70, 1999 - Issue 5
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Original Article

Oxidant status increased during fracture healing in rats

Akin Turgut Department of Orthopaedics and Traumatology, Osmangazi University, School of Medicine, TR-Eskisehir, Turkey, +90 222-2392979, -2309632
,
Erol Göktürk Department of Orthopaedics and Traumatology, Osmangazi University, School of Medicine, TR-Eskisehir, Turkey, +90 222-2392979, -2309632
,
Nusret Köse Department of Orthopaedics and Traumatology, Osmangazi University, School of Medicine, TR-Eskisehir, Turkey, +90 222-2392979, -2309632
,
Murat Kagmaz Department of Biochemistry, Ankara University, School of Medicine, Ankara, Turkey
,
H Serdar Oztiirk Department of Biochemistry, Ankara University, School of Medicine, Ankara, Turkey
,
Sinan Seber Department of Orthopaedics and Traumatology, Osmangazi University, School of Medicine, TR-Eskisehir, Turkey, +90 222-2392979, -2309632
&
Saim Acar Department of Orthopaedics and Traumatology, Osmangazi University, School of Medicine, TR-Eskisehir, Turkey, +90 222-2392979, -2309632
 show all
Pages 487-490 | Published online: 08 Jul 2009
 
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Abstract

We evaluated oxidant status during bone healing in 50 rats. In 40 rats, the right tibia was fractured and fixed intramedullarlyy (study leg) and the left tibia was pinned but not fractured (control leg). Rats were killed on days 1, 3, 7, 14, 28 and malondialdehyde (MDA) levels were determined in tibial bone tissue. The MDA levels of study and control legs were compared with basal MDA levels in bone in 10 rats. There was no apparent difference between the basal level and control legs, but the study legs showed a statistically significant increase in MDA levels on days 7 and 14. We conclude that no oxidative stress injury occurs during the ischemic period of fracture healing, but it may be significant during inflammation and the formation of callus.

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Related Research Data

Dnmt3a-Mediated DNA Methylation Changes Regulate Osteogenic Differentiation of hMSCs Cultivated in the 3D Scaffolds under Oxidative Stress.
Source: Hindawi
OSTEOGENIC CELLS DIFFERENTIATE DURING FRACTURE HEALING
Source: Wiley
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Source: Springer Science and Business Media LLC

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