Analysis of DPP6 and FGGY as candidate genes for amyotrophic lateral sclerosis

Abstract

DPP6 and FGGY genes have been recently associated with an increased susceptibility for sporadic amyotrophic lateral sclerosis. Here, we evaluated the role of these genes in ALS pathogenesis by undertaking a sequence analysis of a cohort of 190 ALS patients from France and Quebec. We did not observe any evidence that mutations in DPP6 and FGGY genes are involved in ALS. Our data indicate that mutations in these genes are unlikely to be a common cause of ALS in the French and French Canadian populations.

Key words::

• Amyotrophic lateral sclerosis
• genetics
• genome-wide association studies
• DPP6
• FGGY

Declaration of interest: The authors declare that no conflicts of interests exist in relation to the present manuscript. This study was supported by the Canadian Institutes of Health Research (CIHR), Muscular Dystrophy Association USA (MDA) and ALS Association (ALSA).