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Journal of Dietary Supplements Volume 13, 2016 - Issue 2
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ARTICLE

Adverse Effects of Grape Seed Extract Supplement: A Clinical Case and Long-Term Follow-Up

Andrew C. BerryKansas City University of Medicine and Biosciences, Kansas City, Missouri, USACorrespondence[email protected]
,
Rahman NakshabendiDepartment of Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA
,
Hussein AbidaliDepartment of Medicine, Banner Good Samaritan Medical Center, Phoenix, Arizona, USA
,
Kunakorn AtchaneeyasakulDepartment of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA
,
Kevin DholariaDepartment of Medicine, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA
,
Cassandra JohnsonUniversity of South Florida, Tampa, Florida, USA
,
Varsha A. KishoreKansas City University of Medicine and Biosciences, Kansas City, Missouri, USA
&
Aaron C. Baltz7GI Associates, Gastroenterology, Milwaukee, Wisconsin, USA
 show all
Pages 232-235 | Published online: 17 Feb 2015
 
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ABSTRACT

Grape seed extract (GSE) supplement use is becoming more popular today for its potential chemopreventive and chemotherapeutic role. We report a 49-year-old male who presented with recurrent nausea, vomiting, diarrhea, and acute weakness following GSE use. A thorough medical workup ensued and no causes were identified clinically, procedurally, or with imaging. Symptoms resolved after GSE discontinuation and the patient remained symptom-free 5 years later. This case illustrates the paucity of documented detailed clinical cases and lack of controlled trials detailing a thorough and reproducible adverse effect profile of GSE supplement.

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