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Abstract
Complete nucleotide sequence of the 27,266 bp mitochondrial genome of the сephalosporin C producing fungus Acremonium chrysogenum have been determined using whole genome shotgun sequencing approach. The circular mapping molecule encodes a usual set of mitochondrial proteins and RNA genes, including large and small ribosomal RNAs, 19 proteins and 26 tRNA genes and contains 2 introns. All structural genes are located on one strand and are apparently transcribed in one direction. Comparative analysis of this and previously sequenced Pezizomycotina mtDNAs revealed more extensive similarity between A. chrysogenum genome and those of Fusarium clade and specific synthenic patterns characteristic of Hypocrealean mitogenomes. Phylogenetic analysis based on catenated mitochondrial protein sequences confirmed current taxonomic position of A. chrysogenum within Hyprocreales and related taxa.
Acknowledgements
Authors are grateful to Yu.E. Bartoshevitch for his valuable advices concerning A. chrysoegenum cultivation and handling.
Declaration of interest
This work was supported by the Russian Foundation for Basic Research (grant 13-04-40206-H of A.V.M.), Program “Molecular and cellular biology” of the Russian Academy of Science (project of N.V.R.) and by a Grant for Leading Scientific Schools of Russia (NS 7200.2012.4).