Advanced search
Publication Cover
Mitochondrial DNA Part A
DNA Mapping, Sequencing, and Analysis
Volume 27, 2016 - Issue 6
Submit an article Journal homepage
93
Views
8
CrossRef citations to date
0
Altmetric
Short Communication

Identification of sequence polymorphisms in the D-Loop region of mitochondrial DNA as a risk factor for colon cancer

Zhanjun GuoDepartment of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, PR China and
,
Shengnan ZhaoDepartment of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, PR China and
,
Haiyan FanDepartment of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, PR China and
,
Yanming DuDepartment of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, PR China
,
Yufei ZhaoDepartment of Gastroenterology and Hepatology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, PR China and
&
Guiying WangDepartment of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, PR ChinaCorrespondence[email protected]
Pages 4244-4245 | Received 28 Sep 2014, Accepted 19 Dec 2014, Published online: 20 May 2016
 
Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days

Abstract

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-Loop) of mitochondrial DNA (mtDNA) has been identified for their association with cancer risk in a number of cancers. We investigated the colon cancer risk profile of D-Loop SNPs in a case–control study. The frequent alleles of nucleotides 73G/A, 146T/C, 195T/C, 324C/G, 16261C/T, and 16304T/C as well as the minor allele of 309C/C insert were significantly associated with an increased risk for colon cancer. In conclusion, SNPs in the mtDNA D-Loop were found to be valuable markers for colon cancer risk evaluation.

Declaration of interest

All authors disclose any financial, consulting, and personal relationships with other people or organizations that could influence their work. This work was supported by Key Basic Research Program of Hebei (14967713D).

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 61.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 6,822.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.