Whole mitochondrial genome sequencing and analysis for chronic obstructive pulmonary disease rat strain

Abstract

Mitochondrial genome plays a central role in aging, cancer, apoptosis and metabolism. We sequenced a complete mitochondrial genome sequence of a rat chronic obstructive pulmonary disease rat strain for the first time. The total length of the mitochondrial genome was 16,310 bp and coding 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes. This genome describing information will supply the potential use of mtDNA mutations as markers in cancer.

Keywords:

• Cancer
• chronic obstructive pulmonary disease
• mitochondrial genome

Declaration of interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.