Altered behavioural responses and functional recovery in rats following sciatic nerve compression and early vs late decompression

Abstract

Objective: The aim of the study was to examine sensory behaviour and functional recovery in rats during nerve compression and after decompression. Compression injury is a far more common condition than nerve transection. The condition is characterised by numbness and a tingling/burning sensation, and some patients experience pain and allodynia during compression or after decompression treatment. The aetiology is in many cases unknown. Thus, further studies are of great importance for the understanding of this condition.

Methods: In the present study, behavioural responses to tactile stimulation, thermal pain, as well as functional sensorimotor behaviour were investigated in rats before, during severe compression, and after decompression. The sciatic nerve of the rats was experimentally compressed for 3 or 28 days, whereafter surgical release, i.e. decompression, of the nerve was performed and the rats were examined up to ∼9 weeks.

Results: An altered behaviour was found in response to compression injury, which is mitigated after early decompression treatment.

Conclusions: These findings indicate that early intervention during severe compression injuries is of great importance for recovery and restoration of nerve function and, thus, should have an impact on clinical routines regarding treatment of compression injuries.

Keywords:

• Nerve injury
• nerve compression
• decompression
• pain
• allodynia
• hyperalgesia
• sensorimotor behaviour

Acknowledgements

We would like to thank Lena Stenberg for excellent technical assistance.

This work was supported by The Swedish Research Council [grant number 4499 and 12712], the Crafoord Foundation, the Johan and Greta Kock Foundation, the Alfred Österlund Foundation, the Thorsten and Elsa Segerfalk Foundation, Region Skåne and Lund University.

Disclosure statement

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.