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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration Volume 14, 2013 - Issue 3
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The FIG4 gene does not play a major role in causing ALS in Italian patients

Simonetta VerdianiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health – University of Genova
,
Paola OrigoneDepartment of Internal Medicine and U.O. Medical Genetics of IRCCS AOU S. Martino – IST, Genova
,
Alessandro GeroldiDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health – University of Genova
,
Monica Bandettini Di PoggioDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics and Maternal Child Health – University of Genova and U.O. Neurology of IRCCS AOU S. Martino – IST, Genova
,
Vittorio ManteroDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics and Maternal Child Health – University of Genova and U.O. Neurology of IRCCS AOU S. Martino – IST, Genova
,
Emilia BelloneDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health – University of Genova, and U.O. Medical Genetics of IRCCS AOU S. Martino – IST, Genova, Italy
,
Gianluigi MancardiDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics and Maternal Child Health – University of Genova and U.O. Neurology of IRCCS AOU S. Martino – IST, Genova
,
Claudia CaponnettoDepartment of Neuroscience, Rehabilitation, Ophtalmology, Genetics and Maternal Child Health – University of Genova and U.O. Neurology of IRCCS AOU S. Martino – IST, Genova
&
Paola MandichDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health – University of Genova, and U.O. Medical Genetics of IRCCS AOU S. Martino – IST, Genova, ItalyCorrespondence[email protected]
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Pages 228-229 | Received 17 Oct 2012, Accepted 16 Dec 2012, Published online: 22 Jan 2013
 
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"The FIG4 gene does not play a major role in causing ALS in Italian patients." Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 14(3), pp. 228–229

Acknowledgements

We thank Miriam H. Meisler, Department of Human Genetics, University of Michigan, USA for kindly providing us primers sequences and PCR conditions for FIG4 amplification.

This work was partly supported by grant ‘La sclerosi laterale amiotrofica (SLA) e le gravi malattie del motoneurone: dai meccanismi molecolari alla presa in carico del paziente’, Regione Liguria, to GLM and PM. The authors are also grateful to patients and their families for participation in the studies and ongoing support.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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