CHCHD10 is not a frequent causative gene in Chinese ALS patients

Abstract

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the death of motor neurons. Recently, mutations in CHCHD10 have been reported to cause ALS in Western populations. In the present study, direct DNA sequencing has been performed on CHCHD10 in a cohort of 294 ALS patients of Chinese Han origin. No mutations were identified in CHCHD10 in ALS cases of Chinese ancestry. We propose CHCHD10 might not be a frequent causal gene among Chinese with ALS.

Key words:

• Amyotrophic lateral sclerosis (ALS)
• CHCHD10
• mutation screening
• mitochondria pathology

Acknowledgements

We are grateful to all the patients for their participation. This study is supported by the Beijing Municipal Science and Technology Commission and the National Natural Science Foundation of China (NSFC).

Declaration of interest

The authors declare no actual or potential conflicts of interest.