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Mitochondrial DNA Part A
DNA Mapping, Sequencing, and Analysis
Volume 28, 2017 - Issue 5
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Research Article

Identification of mitochondrial DNA transfer in canine transmissible venereal tumours obtained from dogs in Mexico

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Pages 645-649 | Received 08 Dec 2015, Accepted 11 Mar 2016, Published online: 20 Apr 2016
 

Abstract

Canine transmissible venereal tumour (CTVT) has been transmitted by cell transplantation from dog to dog, for over 10 000 years. Although initial studies report a single genetic origin for CTVT, recent samples from around the world reveal high genetic diversity. An elevated number of polymorphisms have been determined in mitochondrial DNA (mtDNA) of CTVT. The recent discovery of mtDNA transference from the host into tumoural cells could be a novel source of genetic diversity in CTVT. The aim of this study was to determine the presence of host mtDNA in samples of CTVT in Mexican dogs. Genotyping of 49 samples of CTVT and 49 samples of blood cells pertaining to affected dogs was performed by direct sequencing from the mtDNA D-loop region. Exogenous mtDNA was observed in 6% of the analysed tumours. This is the first investigation reporting the prevalence of exogenous mtDNA in CTVT in the Mexican dog population.

Disclosure statement

The authors report no declaration of interest. The authors alone are responsible for the content and writing of the article.

Funding information

The authors would like to thank the Universidad Autónoma del Estado de México for financial support.

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