Diagnosis and therapy of rheumatoid arthritis in the future

Abstract

Rheumatoid arthritis (RA) is a chronic, inflammatory, systemic disease characterized by joint pain and destruction. We describe the importance of early diagnosis, recording magnetic resonance images images at an early stage, monitoring disease progression using gliostatin purified in our laboratory, and sugar-chain analysis of RA serum IgG. For treatment of RA, cyclooxygenase-2-selective inhibitors, disease-modifying antirheumatic drugs, biological products, and the possibility of gene therapy are discussed. The development of therapeutic methods based on the elucidation of the pathology of RA has progressed markedly in the past decade, and further progress and the development of an early diagnostic method are expected.

Key words::

• Agalactosyl IgG
• Cyclooxygenase (COX)-2 selective inhibitor
• Gliostatin
• Magnetic resonance imaging (MRI)
• Rheumatoid arthritis