Reactive arthritis after influenza vaccination: report of a case

Junichi AsakawaDepartment of Rheumatology, School of Medicine, Juntendo University, Tokyo, Japan

Shigeto KobayashiDepartment of Rheumatology, School of Medicine, Juntendo University, Tokyo, Japan;Department of Medicine, Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya 343-0032, JapanCorrespondence[email protected]

Kazuhiko KanedaDepartment of Rheumatology, School of Medicine, Juntendo University, Tokyo, Japan

Hitoshi OgasawaraDepartment of Rheumatology, School of Medicine, Juntendo University, Tokyo, Japan

Masahiro SugawaraDepartment of Rheumatology, School of Medicine, Juntendo University, Tokyo, Japan

Masahiko YasudaDepartment of Medicine, Nakaizu Onsen Hospital, Tagatagun, Shizuoka, Japan

Hiroshi HashimotoDepartment of Rheumatology, School of Medicine, Juntendo University, Tokyo, Japan;Department of Medicine, Juntendo Koshigaya Hospital, 560 Fukuroyama, Koshigaya 343-0032, Japan

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Abstract

We describe a patient with reactive arthritis (ReA) induced by influenza vaccination. A healthy 79-year-old Japanese man began suffering from migrating polyarthritis 2 days after receiving influenza vaccine. He proved negative for rheumatoid factor, showing no evidence for microbial infections such as Streptoccocci, Chlamydia, or Parbovirus B19. Human leukocyte antigen (HLA) typing analysis revealed positive results for HLA-B54 (22), which is one of the cross-reactive antigens to HLA-B27. His arthritis improved with administration of nonsteroidal anti-inflammatory drugs, and recovery was attained within 6 weeks. Reactive arthritis is a rare adverse effect induced by influenza vaccination; however, it is important that it is recognized by all physicians.

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Reactive arthritis after influenza vaccination: report of a case

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Reactive arthritis after influenza vaccination: report of a case

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