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Original Articles

Antidepressant drug interactions in the elderly

Understanding the P-450 system is half the battle in reducing risks

, MD
Pages 231-249 | Published online: 30 Jun 2015
 

PREVIEW

As patients age, pharmacologic treatment of depression becomes more complicated because of the increased risk of drug interactions in the elderly. Choosing an appropriate agent requires a thorough knowledge of cytochrome P-450 enzymes, which affect drug metabolism in the liver. In this article, Dr Cadieux explains the critical factors affecting antidepressant treatment in elderly patients and discusses potential and documented drug interactions of selected agents.

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