Clinical Application of Microsampling Versus Conventional Sampling Techniques in the Quantitative Bioanalysis of Antibiotics: A Systematic Review

Abstract

Conventional sampling techniques for clinical pharmacokinetic studies often require the removal of large blood volumes from patients. This can result in a physiological or emotional burden, particularly for neonates or pediatric patients. Antibiotic pharmacokinetic studies are typically performed on healthy adults or general ward patients. These may not account for alterations to a patient’s pathophysiology and can lead to suboptimal treatment. Microsampling offers an important opportunity for clinical pharmacokinetic studies in vulnerable patient populations, where smaller sample volumes can be collected. This systematic review provides a description of currently available microsampling techniques and an overview of studies reporting the quantitation and validation of antibiotics using microsampling. A comparison of microsampling to conventional sampling in clinical studies is included.

Keywords:

• antibiotics
• clinical
• microsampling
• pharmacokinetics
• quantitative

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.4155/bio-2017-0269

Financial & competing interests disclosure

JA Roberts is a recipient of an Australian National Health and Medical Research Council Fellowship (APP1048652). SL Parker is a recipient of an Australian National Health and Medical Research Council Fellowship (APP1142757). The authors acknowledge the funding from the Australian National Health and Medical Research Council for Project Grants (APP1044941, APP1062040) and Centre of Research Excellence (APP1099452). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at: www.tandfonline.com/doi/suppl/10.2144/000112170

Additional information

Funding

JA Roberts is a recipient of an Australian National Health and Medical Research Council Fellowship (APP1048652). SL Parker is a recipient of an Australian National Health and Medical Research Council Fellowship (APP1142757). The authors acknowledge the funding from the Australian National Health and Medical Research Council for Project Grants (APP1044941, APP1062040) and Centre of Research Excellence (APP1099452). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.